Spravato for Depression

What is Spravato® (esketamine)?

Spravato is an FDA-approved prescription nasal spray used under medical supervision to treat depression.

It may be recommended for adults experiencing:

• • Treatment-resistant depression (after trying two or more antidepressants)
  • Major depressive disorder with suicidal thoughts or actions

Is Spravato the same as ketamine?

Not exactly.

Spravato (esketamine) is derived from ketamine but is specifically formulated as a nasal spray and administered in a controlled medical setting.

Because it is more targeted, it may be used at lower doses and can offer a different treatment experience than IV ketamine.

Will my insurance cover Spravato?

How do I get started?

Your first step is a consultation with one of our board-certified Psychiatric Mental Health Nurse Practitioners.

During this visit, we’ll review:

• • Your symptoms
  • Treatment history
  • Whether Spravato may be a good fit

If you’ve received care elsewhere, bringing past records can be helpful.

What should I expect during treatment?

Treatment takes place in a comfortable, private setting.

• • You’ll be seated in a reclining chair
  • Sessions include a 2-hour observation period
  • You can bring items like headphones, a blanket, or a book

Many patients choose to rest quietly during treatment.

Are there side effects?

Like all medications, Spravato may cause side effects.

The most common include:

• • Feeling disconnected or “out of body”
  • Dizziness or nausea
  • Drowsiness or fatigue
  • Temporary changes in mood or perception

These effects typically occur shortly after treatment and resolve the same day.

What happens after treatment?